Runes and Bone Charms are still your key tools for character customization and growth, but in
The Brigmore Witches, you have the option to find and equip Corrupted Bone Charms. These are like other Bone Charms, but with a serious twist: the benefits they provide are incredible, but they all come with a penalty. For example, Statuesque makes Daud invisible to enemies when standing still, but it also prevents his mana from regenerating.
The Brigmore Witches comes with a new power for you to try out: Pull. It's essentially telekinesis, Dishonored-style. Level 1 allows Daud to pull items towards him. This can include consumables, currency, and even whale oil tanks used to power security machines. Level 2 allows Daud to rip bodies, quick and dead, towards you. It's high-profile witchcraft, but it's fun to use.
There's also a new gadget for Daud to try, and it's Baffle Dust, a variant on Chokedust that leaves enemies confused and oblivious once they're done with their coughing fit.
Other than all of that, all of Daud's abilities from The Knife of Dunwall come into play here. He can summon assassins, pay for certain favors, and upgrade his equipment between missions. Depending on your playstyle, you'll get through the content without seeing and doing everything you could. So, of course, that invites replay.